Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer’s Disease
Identifieur interne : 00E328 ( Main/Exploration ); précédent : 00E327; suivant : 00E329Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer’s Disease
Auteurs : Min Kim [Royaume-Uni] ; Alejo Nevado-Holgado [Royaume-Uni] ; Luke Whiley [Royaume-Uni] ; Stuart G. Snowden [Royaume-Uni] ; Hilkka Soininen [Finlande] ; Iwona Kloszewska [Pologne] ; Patrizia Mecocci [Italie] ; Magda Tsolaki [Grèce] ; Bruno Vellas [France] ; Madhav Thambisetty [États-Unis] ; Richard J. B. Dobson [Royaume-Uni] ; John F. Powell [Royaume-Uni] ; Michelle K. Lupton [Australie] ; Andy Simmons [Royaume-Uni] ; Latha Velayudhan [Royaume-Uni] ; Simon Lovestone [Royaume-Uni] ; Petroula Proitsi [Royaume-Uni] ; Cristina Legido-Quigley [Royaume-Uni]Source :
- Journal of Alzheimer's Disease [ 1387-2877 ] ; ????.
Abstract
Lipids such as ceramides and phosphatidylcholines (PC) have been found altered in the plasma of Alzheimer’s disease (AD) patients in a number of discovery studies. For this reason, the levels of 6 ceramides and 3 PCs, with different fatty acid length and saturation levels, were measured in the plasma from 412 participants (AD
Url:
DOI: 10.3233/JAD-160645
PubMed: 27911300
PubMed Central: 5676755
Affiliations:
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Kim</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Pharmaceutical Science,<institution>King’s College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nevado Holgado, Alejo" sort="Nevado Holgado, Alejo" uniqKey="Nevado Holgado A" first="Alejo" last="Nevado-Holgado">Alejo Nevado-Holgado</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Psychiatry,<institution>University of Oxford</institution>, Oxford,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Whiley, Luke" sort="Whiley, Luke" uniqKey="Whiley L" first="Luke" last="Whiley">Luke Whiley</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Pharmaceutical Science,<institution>King’s College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Snowden, Stuart G" sort="Snowden, Stuart G" uniqKey="Snowden S" first="Stuart G." last="Snowden">Stuart G. Snowden</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Pharmaceutical Science,<institution>King’s College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Neurology,<institution>Kuopio University Hospital and University of Eastern Finland</institution>, Kuopio,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kloszewska">Iwona Kloszewska</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Old Age Psychiatry & Psychotic Disorders,<institution>Medical University of Lodz</institution>, Lodz,<country>Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name><affiliation wicri:level="1"><nlm:aff id="aff5">Section of Gerontology and Geriatrics, Department of Medicine,<institution>University of Perugia</institution>, Perugia,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name><affiliation wicri:level="1"><nlm:aff id="aff6">Third Department of Neurology, Memory and Dementia Centre, Medical School,<institution>Aristotle University of Thessaloniki</institution>, Thessaloniki,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name><affiliation wicri:level="1"><nlm:aff id="aff7">Department of Internal and Geriatrics Medicine, INSERM U 1027, Gerontopole, Hôpitaux de Toulouse, Toulouse,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thambisetty, Madhav" sort="Thambisetty, Madhav" uniqKey="Thambisetty M" first="Madhav" last="Thambisetty">Madhav Thambisetty</name><affiliation wicri:level="1"><nlm:aff id="aff8">Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience,<institution>National Institute on Aging</institution>, Baltimore, MD,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dobson, Richard J B" sort="Dobson, Richard J B" uniqKey="Dobson R" first="Richard J. B." last="Dobson">Richard J. B. Dobson</name><affiliation wicri:level="1"><nlm:aff id="aff9">Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F." last="Powell">John F. Powell</name><affiliation wicri:level="1"><nlm:aff id="aff9">Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lupton, Michelle K" sort="Lupton, Michelle K" uniqKey="Lupton M" first="Michelle K." last="Lupton">Michelle K. Lupton</name><affiliation wicri:level="1"><nlm:aff id="aff10">Genetic Epidemiology,<institution>QIMR Berghofer Medical Research Institute</institution>, Brisbane, Qld,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simmons, Andy" sort="Simmons, Andy" uniqKey="Simmons A" first="Andy" last="Simmons">Andy Simmons</name><affiliation wicri:level="1"><nlm:aff id="aff9">Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) for Mental Health at South London and Maudsley NHS Foundation Trust</institution>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Velayudhan, Latha" sort="Velayudhan, Latha" uniqKey="Velayudhan L" first="Latha" last="Velayudhan">Latha Velayudhan</name><affiliation wicri:level="1"><nlm:aff id="aff9">Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Psychiatry,<institution>University of Oxford</institution>, Oxford,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Proitsi, Petroula" sort="Proitsi, Petroula" uniqKey="Proitsi P" first="Petroula" last="Proitsi">Petroula Proitsi</name><affiliation wicri:level="1"><nlm:aff id="aff9">Institute of Psychiatry, Psychology & Neuroscience,<institution>King’s College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Legido Quigley, Cristina" sort="Legido Quigley, Cristina" uniqKey="Legido Quigley C" first="Cristina" last="Legido-Quigley">Cristina Legido-Quigley</name><affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Pharmaceutical Science,<institution>King’s College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Alzheimer's Disease</title><idno type="ISSN">1387-2877</idno><idno type="eISSN">1875-8908</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lipids such as ceramides and phosphatidylcholines (PC) have been found altered in the plasma of Alzheimer’s disease (AD) patients in a number of discovery studies. For this reason, the levels of 6 ceramides and 3 PCs, with different fatty acid length and saturation levels, were measured in the plasma from 412 participants (AD <italic>n</italic> = 205, Control <italic>n</italic> = 207) using mass spectrometry coupled with ultra-performance liquid chromatography. After this, associations with AD status, brain atrophy, and age-related effects were studied. In the plasma of AD participants, cross-sectional analysis revealed elevated levels of three ceramides (Cer16:0 <italic>p</italic> < 0.01, Cer18:0 <italic>p</italic> < 0.01, Cer24:1 <italic>p</italic> < 0.05). In addition, two PCs in AD plasma (PC36:5 <italic>p</italic> < 0.05, PC38:6 <italic>p</italic> < 0.05) were found to be depleted compared to the control group, with PC36:5 also associating with hippocampal atrophy (<italic>p</italic> < 0.01). Age-specific analysis further revealed that levels of Cer16:0, Cer18:0, and Cer20:0 were associated with hippocampal atrophy only in younger participants (age < 75, <italic>p</italic> < 0.05), while all 3 PCs did so in the older participants (age > 75, <italic>p</italic> < 0.05). PC36:5 was associated with AD status in the younger group (<italic>p</italic> < 0.01), while PC38:6 and 40:6 did so in the older group (<italic>p</italic> < 0.05). In this study, elevated ceramides and depleted PCs were found in the plasma from 205 AD volunteers. Our findings also suggest that dysregulation in PC and ceramide metabolism could be occurring in different stages of AD progression.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Italie</li><li>Pologne</li><li>Royaume-Uni</li><li>États-Unis</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Kim, Min" sort="Kim, Min" uniqKey="Kim M" first="Min" last="Kim">Min Kim</name></noRegion><name sortKey="Dobson, Richard J B" sort="Dobson, Richard J B" uniqKey="Dobson R" first="Richard J. B." last="Dobson">Richard J. B. Dobson</name><name sortKey="Legido Quigley, Cristina" sort="Legido Quigley, Cristina" uniqKey="Legido Quigley C" first="Cristina" last="Legido-Quigley">Cristina Legido-Quigley</name><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><name sortKey="Nevado Holgado, Alejo" sort="Nevado Holgado, Alejo" uniqKey="Nevado Holgado A" first="Alejo" last="Nevado-Holgado">Alejo Nevado-Holgado</name><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F." last="Powell">John F. Powell</name><name sortKey="Proitsi, Petroula" sort="Proitsi, Petroula" uniqKey="Proitsi P" first="Petroula" last="Proitsi">Petroula Proitsi</name><name sortKey="Simmons, Andy" sort="Simmons, Andy" uniqKey="Simmons A" first="Andy" last="Simmons">Andy Simmons</name><name sortKey="Simmons, Andy" sort="Simmons, Andy" uniqKey="Simmons A" first="Andy" last="Simmons">Andy Simmons</name><name sortKey="Snowden, Stuart G" sort="Snowden, Stuart G" uniqKey="Snowden S" first="Stuart G." last="Snowden">Stuart G. Snowden</name><name sortKey="Velayudhan, Latha" sort="Velayudhan, Latha" uniqKey="Velayudhan L" first="Latha" last="Velayudhan">Latha Velayudhan</name><name sortKey="Whiley, Luke" sort="Whiley, Luke" uniqKey="Whiley L" first="Luke" last="Whiley">Luke Whiley</name></country><country name="Finlande"><noRegion><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kloszewska">Iwona Kloszewska</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name></noRegion></country><country name="Grèce"><noRegion><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name></noRegion></country><country name="France"><noRegion><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Thambisetty, Madhav" sort="Thambisetty, Madhav" uniqKey="Thambisetty M" first="Madhav" last="Thambisetty">Madhav Thambisetty</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Lupton, Michelle K" sort="Lupton, Michelle K" uniqKey="Lupton M" first="Michelle K." last="Lupton">Michelle K. 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